After the arrival of 1st batch of Russian Sputnik V vaccine in India at the end of April, people want to know the availability of Sputnik vaccine, its price, registration, effectiveness, efficiency, dose and side-effect.
In month of May 27, 2021 Domestic pharma firm Panacea Biotec NSE -2.01 percent has launched manufacture of the ‘Sputnik V’ COVID-19 vaccine in India in collaboration with Russian sovereign wealth fund RDIF.
Sputnik V vaccine in India News
The Russian Direct Investment Fund (RDIF), which offers the vaccine abroad, and Panacea Biotec agreed in April to produce 100 million doses of Sputnik V Vaccine in India.
According to the Press Release: The first batch of the COVID-19 vaccine manufactured at Panacea Biotec’s Baddi facility in Himachal Pradesh will be transferred to Russia’s Gamaleya Center for “quality control,”.
Later The Serum Institute of India (SII) in Pune has signed an agreement with the Russian Direct Investment Fund (RDIF) to manufacture the Sputnik V vaccine in India beginning in September.
Sputnik V Vaccine, also known as Gam-COVID-Vac, is a COVID-19 adenovirus viral vector vaccine produced by Russia’s Gamaleya Research Institute of Epidemiology and Microbiology.
On August 11, 2020, the Russian Ministry of Health approved the world’s first registered combination vector vaccination for the prevention of COVID-19.
According to Kirill Dmitriev, CEO of the Russian Direct Investment Fund, the ‘V’ in its name stands for ‘Victory [against COVID-19].’
Gam-COVID-Vac was licenced for distribution in Russia first, and later in 59 additional countries (as of April 2021) based on the preliminary results of Phase I–II studies, which were eventually published on September 4, 2020.
The licencing of Gam-COVID-Vac in early August drew criticism in the media and sparked debate in the scientific community about whether approval was acceptable given the absence of strong scientific data showing safety and efficacy.
Sputnik V Vaccine Registration in India:
From June 30, private hospitals in Delhi-NCR began providing the Russian vaccine ‘Sputnik V.’ The vaccination is priced at Rs 1,145 per dosage, and pre-registration is required through the Cowin application.
Apollo and Fortis hospitals are among those that have made the vaccine available in the city. “Indraprastha Apollo has begun the administration of the Sputnik V vaccination for the public in a staged way beginning June 30th,” an Apollo Hospitals spokeswoman stated, adding that over 1,000 people have already received the vaccine.
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Medical uses of the Sputnik Vaccine
The vaccine is available in two forms: as a ready-to-use solution in water that is frozen at the normal home-freezer storage temperature of 18 °C or 0 °F or below, and as a freeze-dried (lyophlilized) powder called “Gam-COVID-Vac-Lyo” that can be stored at 2–8 °C or 36–46 °F.
Before using the freeze-dried powder, it must be reconstituted with sterile water. Gam-COVID-lyophilized Vac’s formulation is similar to the smallpox vaccine, eliminating the need for continuous “colder chain” or cold-chain storage – as required for the Pfizer–BioNTech and Moderna vaccines – and permitting shipment to remote sites with decreased danger of vaccine deterioration.
The Sputnik V Vaccine Efficiency –
Based on clinical testing and analysis of 19,866 volunteers who received both the first and second doses, the Sputnik V Vaccine demonstrated 91.6 percent efficacy with no unusual side-effects. After phase 1 and phase 2 clinical studies, international peer-reviewed data published in The Lancet substantiated efficacy.
With those aged 60 and older, the claimed effectiveness was 91.8 percent. On May 12, a group of biostatisticians from Russia, the United States, France, Italy, and the Netherlands questioned the comparative effectiveness results in a letter published in The Lancet, pointing out data discrepancies, poor reporting, obvious errors and numerical inconsistencies, and a very unlikely homogeneity in vaccine efficacy across age groups.
Sputnik V COVID-19 vaccine has 97.6 percent efficiency, according to latest data based on 3.8 million persons vaccinated with two doses in Russia.
In Phase 3 clinical preliminaries, the Sputnik V Vaccine showed solid security, immunogenicity and viability results.
During the preliminary, 98% of individuals in the antibody bunch fostered a humoral invulnerable reaction and 100% cell resistant reaction.
Immunization recorded 91.8% adequacy for the older gathering.
After vaccination, individuals created infection killing antigen explicit IgG antibodies that is 1.3 to 1.5 occasions higher than the COVID-19 recuperated patients.
The Sputnik V Vaccine Effectiveness –
A vaccine is considered to be effective if the estimate is >50% with a >30% lower limit of the 95 percent computed from the observed data. It is widely predicted that effectiveness will gradually degrade over time.
Denis Logunov, the Gamaleya Institute’s director, claimed on June 29, 2021, that Sputnik V is around 90% effective against the Delta version.
A preliminary version of a case-control study published on August 25 suggested an uncorrected efficiency of roughly 50% against symptomatic illness.
What is the Sputnik v vaccine price in India?
The Sputnik V Vaccination price in India is at Rs 1,145 per dosage, and to get the dose of this vaccine you must pre-register through the Cowin official website or other authority apps.
On 21st June 2021 under new immunization strategy Shri Narendra Modi, Prime Minister of INDIA declared all over the age of 18 would get free antibody. The two-portion Sputnik V Vaccination at present directed in INDIA liberated from cost to everybody through the Center apportioned to states and association domains dependent on models, for example, sickness weight, populace and inoculation progress.
Focal government will purchase 75% of vaccines from the producer in INDIA and disperse to states. Private emergency clinics can secure the rest 25% of the vaccines from the maker.
According to the Government of India directions, the private medical clinics might energize to a limit of Rs 150 for every portion as administration charges per portion, separate state government will screen these charges.
The greatest retails cost for each portion of the Sputnik V Vaccine is Rs 995 comprehensive of all charges. The first portion contains 0.5 ml rAD26 (recombinant adenovirus serotype 26 particles), while the second portion contains 0.5 ml rAD5 (recombinant adenovirus serotype 5 particles).
Consolidating the most extreme retails cost and administration charges at private medical clinics, the immunization cost for each portion of the Sputnik V Vaccine cost in India would cost Rs 1,145 comprehensive of all expenses.
Availability Sputnik V Vaccine in India
Locally produced Sputnik V vaccines against Covid-19 are expected to be available in India by September or October, according to Dr Reddy’s Laboratories.
A statement from to Dr Reddy’s Laboratories says – “We have received 31.5 lakh doses of component 1 and 4.5 lakh doses of component 2 of the Sputnik V vaccine in India. To increase supply, we are collaborating closely with the Russian Direct Investment Fund (RDIF).
We are also working closely with our partners in India for manufacturing readiness,” ANI reported quoting a release by the company.
We have worked with key hospitals across the country to establish our cold chain infrastructure spanning more than 300 locations, as the vaccine requires -18°C temperatures,” according to the announcement.
In the release, the RDIF cited Serum Institute of India (SII), a Pune-based vaccine maker, as one of several pharmaceutical businesses with which it has collaborated to develop Sputnik V vaccine in India.
Notably, SII will begin producing over 300 million doses of the Russian vaccine each year this year. RDIF, on the other hand, has partnered with Dr. Reddy’s Labs to market the first 250 million doses of Sputnik V vaccine in India.
From the end of May Sputnik Vaccine is available in many states of India. Initially it is available only on private hospitals but sooner from September it will be available from government hospitals for free.
Side effects of Sputnik V Vaccine
The majority of the side effects are moderate and similar to those seen with other adenovirus vector vaccines. However, there is no indication of vaccine-induced immune thrombotic thrombocytopenia.
The vaccine has been licensed by 64 nations, including Russia. Argentina, Iran, and India are among these nations. The European Medicines Agency is now reviewing the vaccination in the European Union.
Sputnik vaccine is a two-part adenovirus viral vector vaccination with a 91.6 percent efficacy rate Trusted Source.
Adenoviruses are viruses that cause the common cold and other ailments. They act as a vehicle for the DNA instructions needed to create the SARS-CoV-2 virus’s spike protein in the body. This causes the immune system to produce antibodies against the spike protein, preparing it for an infection.
Some of the common side effects of Sputnik Vaccine are:
- Agony, redness
- Asthenia (absence of energy)
- Exhaustion (feeling tired)
- Body and muscle pain
- Sore throat
- Runny nose
- Fever and Chills
- Queasiness and Vomiting
- Looseness of the bowels
Typically, side effects disappear within 24 to 48 hours; however, if any side effects continue for more than 48 hours, contact the vaccination center.
After vaccination, there was no evidence of major side effects or anaphylactic shock.
Frequently asked Questions
The World Health Organization (WHO) has postponed the review of Russia’s Sputnik V COVID vaccination.
According to a regional WHO official, the jab’s manufacturing procedure did not meet the required criteria.
Russia first requested WHO approval for its vaccine in February, but has yet to acquire an Emergency Use Listing (EUL).
According to the WHO, the vaccine’s approval has been delayed until a new inspection can be performed at one of the factories where Sputnik V was manufactured.
The majority of people who contract COVID-19 are unvaccinated. However, because immunizations are not 100% effective at preventing infection, some people who have been fully vaccinated may still get COVID-19.
More research is needed to determine the efficacy of the existing COVID vaccines against the variations.
An increasing amount of evidence shows that most vaccinations induce adequate immunity to maintain significant effectiveness against most variations, particularly in the case of severe illness, hospitalization, and death.
The variations have a greater influence on efficacy against mild illness and infection without disease than on efficacy against more severe outcomes.
Yes, on clinical trials is proved that the Sputnik Vaccine is effective against the Delta Variant of COVID 19 virus.
All vaccines have been rigorously studied to ensure that they will not harm you. It can take many years for a vaccine to go through the trials and tests required for approval.
The symptoms of the Delta variation are the same. If vaccinated people get the Delta variety, they are usually asymptomatic or have very mild symptoms. Their symptoms are similar to those of a normal cold, such as a cough, fever, or headache, but they also have a substantial loss of smell.
Vaccination prevents you against becoming very ill or dying as a result of COVID-19. You do not have substantial amounts of protection for the first fourteen days after receiving a vaccine, but this progressively rises.
Immunity to a single dose vaccine usually develops two weeks following immunization. Both doses of a two-dose vaccination are required to obtain the maximum level of protection achievable.
While a COVID-19 vaccination will prevent you from serious disease and death, we are still discovering about how well it will keep you from being infected and spreading the virus to others (transmission).
So, you should always follow local authorities’ advice depending on the circumstances and danger where you reside.